Thursday, December 6, 2012

Molina Wins GIBBY For Defensive Player Of The Year | FOX2now ...

Posted on: 5:30 pm, December 4, 2012, by Staff Writer, updated on: 05:27pm, December 4, 2012

Molina117

(KTVI)- Yadier Molina can add another defensive honor to his list. He?s been awarded a 2012 Greatness in Baseball Yearly Award (GIBBY) as the Majors? Defensive Player of the Year.

GIBBY Awards are presented annually by MLB.com and are chosen through votes by media, front-office personnel, MLB alumni, fans at MLB.com, and the Society of American Baseball Research.

Molina was one of 15 finalists from both leagues for the top defensive honor.

This year Molina has also won a fifth straight Gold Glove, his second National League Platinum Glove Award, a Fielding Bible Award, and the Wilson Sporting Goods defensive award.

Molina has been named St. Louis? Baseball Man of the Year. He finished fourth in the voting for the NL?s MVP Award.

This year?s GIBBY Awards featured nominees in 21 categories. Individual honors went to the MLB MVP, in addition to the year?s best starting pitcher, hitter, closer, setup man, rookie, breakout hitter, breakout pitcher, comeback player, manager, executive and postseason performer.

Cardinals? general manager John Mozeliak and manager Mike Matheny were among GIBBY finalists this year.

Source: http://fox2now.com/2012/12/04/molina-wins-gibby-for-defensive-player-of-the-year/

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Wednesday, December 5, 2012

NATO warns Syria not to use chemical weapons

BRUSSELS/BEIRUT (Reuters) - NATO told Syrian President Bashar al-Assad on Tuesday that any use of chemical weapons in his fight against encroaching rebel forces would be met by an immediate international response.

The warning from NATO Secretary-General Anders Fogh Rasmussen came as U.S. government sources said Washington had information that Syria was making what could be seen as preparations to use its chemical arsenal.

Syrian forces meanwhile bombarded rebel districts near Damascus in a sustained counter-attack to stem rebel gains around Assad's power base as the insurgency may be entering a decisive phase.

International concern over Syria's intentions has been heightened by reports that its chemical weapons have been moved and could be prepared for use.

"The possible use of chemical weapons would be completely unacceptable for the whole international community and if anybody resorts to these terrible weapons I would expect an immediate reaction from the international community," Rasmussen told reporters at the start of a meeting of alliance foreign ministers in Brussels.

The chemical threat made it urgent for the alliance to send Patriot anti-missile missiles to Turkey, Rasmussen said.

The French Foreign Ministry referred to "possible movements on military bases storing chemical weapons in Syria" and said the international community would react if they were used.

Britain has told the Syrian government that any use of chemical weapons would have "serious consequences", Foreign Secretary William Hague said.

U.S. President Barack Obama on Monday told Assad not to use chemical weapons, without saying how the United States might respond. The Foreign Ministry in Damascus said it would never use such weapons against Syrians.

CLASSIFIED INTELLIGENCE

The U.S. has collected what has been described as highly classified intelligence information demonstrating that Syria is making what could be construed as preparations to use elements of its extensive chemical weapons arsenal, two U.S. government sources briefed on the issue said.

One of the sources said that there was no question that the US "Intelligence community" had received information pointing to "preparations" under way in Syria related to chemical weapons. The source declined to specify what kind of preparations had been reported, or how close the intelligence indicated the Syrians were to deploying or even using the weapons.

Western military experts say Syria has four suspected chemical weapons sites, and it can produce chemical weapons agents including mustard gas and sarin, and possibly also VX nerve agent. The CIA has estimated that Syria possesses several hundred liters of chemical weapons and produces hundreds of tonnes of agents annually.

The fighting around Damascus has led foreign airlines to suspend flights and prompted the United Nations and European Union to reduce their presence in the capital, adding to a sense that the fight is closing in.

The army fightback came a day after the Syrian foreign ministry spokesman was reported to have defected in a potentially embarrassing blow to the government.

The Syrian Observatory for Human Rights said 200 people were killed across Syria on Monday, more than 60 of them around Damascus. Assad's forces bombarded districts to the south-east of the capital on Tuesday, near to the international airport, and in the rebel bastion of Daraya to the south-west.

Opposition footage posted on the Internet showed a multiple rocket launcher fire 20 rockets, which activists said was filmed at the Mezze military airport in Damascus.

Reuters could not independently verify the footage due to the government's severe reporting restrictions.

In central Damascus, shielded for many months from the full force of a civil war in which 40,000 people have been killed, one resident reported hearing several loud explosions.

"I have heard four or five thunderous blows. It could be barrel bombs," she said, referring to makeshift bombs which activists say Assad's forces have dropped from helicopters on rebel-dominated areas.

MORTAR ATTACK

The state news agency said that 28 students and a teacher were killed near the capital when rebels fired a mortar bomb on a school. Rebels have targeted government-held residential districts of the capital.

The mainly Sunni Muslim rebel forces have made advances in recent weeks, seizing military bases, including some close to Damascus, from forces loyal to Assad, who is from Syria's Alawite minority linked to Shi'ite Islam.

Faced with creeping rebel gains across the north and east of the country, and the growing challenge around the capital, Assad has increasingly resorted to air strikes against the insurgents.

A diplomat in the Middle East said Syrian Foreign Ministry spokesman Jihad Makdissi had left the country and defected, while the British-based Observatory said it had information that he flew from Beirut on Monday afternoon heading for London.

In Beirut, a diplomat said Lebanese officials had confirmed that Makdissi spent several days in Beirut before leaving on Monday, but could not confirm his destination.

"We're aware of reports that he has defected and may be coming to the UK. We're seeking clarification," a Foreign Office spokeswoman in London said.

Makdissi was the public face to the outside world of Assad's government as it battled the 20-month-old uprising. But he had barely appeared in public for several weeks before Monday's report of his defection.

He had little influence in a system largely run by the security apparatus and the military. But Assad's opponents will see the loss of such a high profile figure, if confirmed, as further evidence of a system crumbling from within.

The United Nations and European Union both said they were reducing their presence in Syria in response to the escalated violence around the capital.

A spokesman for U.N. humanitarian operations said the move would not stop aid deliveries to areas which remained accessible to relief convoys.

"U.N.-funded aid supplies delivered through SARC (Syrian Arab Red Crescent) and other charities are still moving daily where the roads are open," Jens Laerke told Reuters in Geneva.

"We have not suspended our operation, we are reducing the non-essential international staff."

Three remaining international staff at the European Union delegation, who stayed on in Damascus after the departure of most Western envoys, crossed the border into Lebanon on Tuesday after pulling out of the Syrian capital.

(Additional reporting by David Brunnstrom in Brussels, Khaled Yacoub Oweis in Cairo, Erika Solomon, Oliver Holmes and Ayat Basma in Beirut, Mark Hosenball, Mohammed Abbas and David Cutler in London, and Stephanie Nebehay in Geneva; Editing by Giles Elgood)

Source: http://news.yahoo.com/syrian-spokesman-flees-country-diplomat-says-105734071.html

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And the most overpaid actor award goes to: Eddie Murphy

NEW YORK (Reuters) - Eddie Murphy was once among Hollywood's top box office draws, but he now has the dubious honor of being crowned its most overpaid actor, according to Forbes magazine.

In its annual list, determined by the misalignment between star salaries and their films' box office take, Murphy, once a one-man gold mine with 1980s hits such as "Trading Places" and "Beverly Hills Cop", displaced Drew Barrymore for the top spot.

"Murphy's career has just collapsed," Forbes said, citing such recent box office bombs as "Imagine That", "A Thousand Words" and "Meet Dave".

Weighing box office receipts against paychecks, Forbes calculated that for every dollar Murphy was paid for his last three films, they returned an average of just $2.30 at the box office. Murphy placed second on the list a year ago.

Popular actresses such as Katherine Heigl, and Oscar winners Reese Witherspoon and Sandra Bullock, made the top five, with "returns" ranging from $3.40 to $5.

Forbes took issue with Witherspoon's "questionable" choices such as the star-laden, James L. Brooks romantic comedy "How Do You Know", which was one of 2010's worst-performing films. It cost $120 million, much of which went toward star salaries, but grossed a paltry $49 million.

The cast included two-time Oscar winner Denzel Washington, as well as actors generally considered solid at the box office such as Adam Sandler and Ben Stiller.

"Washington's films do fine at the box office but he can demand an outsized paycheck on those movies," Forbes noted. His current hit "Flight" was not included for this year's list.

Washington's return was the same $6.30 calculated for Sandler, whose comedies Forbes said were consistent performers -- except when they're not, such as the disappointing "Jack and Jill".

It was the same with Stiller, whom Forbes said "earns so much money per film that one miss can make him seem overpaid. That's what happened with "Tower Heist", in which the actor co-starred with -- Eddie Murphy.

Will Ferrell, who topped the list for two of the last four years and came in third a year ago, didn't place.

The full list can be found at www.forbes.com/overpaidactors.

(Reporting by Chris Michaud; editing by Patricia Reaney and Andrew Hay)

Source: http://news.yahoo.com/most-overpaid-actor-award-goes-eddie-murphy-190408800.html

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Citigroup cutting 11,000 jobs, taking $1 billion in charges

(Reuters) - Citigroup Inc, which has lagged behind its peers in recovering from the financial crisis, said it is cutting 11,000 jobs worldwide, about 4 percent of its staff, to save as much as $1.1 billion a year in expenses.

The move will initially result in pre-tax charges of $1 billion against fourth-quarter earnings, the No. 3 U.S. bank by assets said on Wednesday.

The cuts are Chief Executive Michael Corbat's first major steps to reorganize the company since he took the reins in October after directors pushed out his predecessor, Vikram Pandit.

Investors welcomed the news. Citigroup shares were up 5.3 percent to $36.11 in morning trading on the New York Stock Exchange.

"We have identified areas and products where our scale does not provide for meaningful returns," Corbat said in a statement issued by the company. "We will further increase our operating efficiency by reducing excess capacity and expenses."

The job cuts are part of a reorganization that will reduce annual revenues by "less than $300 million," the bank said.

The bank has been in a long slog to recover from financial crisis losses, which prompted multiple government bailouts. While it has shed hundreds of billions of dollars of troubled assets, analysts have long been impatient with its failure to scale back costs enough to match reduced demand for its services.

Analysts have been expecting dramatic steps since Corbat was brought in as CEO by Citigroup Chairman Michael O'Neill. O'Neill is known in the banking industry for shrinking companies to eliminate businesses that are not earning satisfactory returns.

"Corbat has a limited window of opportunity here in which he can make his new CEO moves," said Nancy Bush, a long-time bank analyst and a contributing editor at SNL Financial. Given the mandate he has to act, she said, "you might as well get the shocking numbers out first."

Still, Bush expects Corbat will continue reorganizing and cutting jobs for two years. "I look at this as the first cut," she said. "Corbat will be forever digging and looking for places to cut, and inevitably personnel will be the biggest part of that."

The job cuts announcement came a few hours before Citigroup Chief Financial Officer John Gerspach was scheduled to speak at midday at a major conference of institutional investors in New York.

CONSUMER BANKING CUTS

About 35 percent of the fourth-quarter restructuring charges will be taken in the global consumer banking unit, where 6,200 jobs will be cut, the bank said. About 40 percent of those layoffs will be in technology and operations support areas.

The bank expects to sell or scale back consumer operations in Pakistan, Paraguay, Romania and Uruguay. As it continues to focus on 150 high-growth markets, it plans to shed 84 branches in five countries, more than half of them in the United States.

After the restructuring, the bank will have 4,000 branches around the world.

Bush said the bank had a "silly strategy" in the mid-2000s, when it was adding branches in areas such as Boston and the New York suburbs. "They now need to go back and rethink their whole domestic branch strategy, and international as well," she said.

When Citigroup changed CEOs in October, O'Neill said executives would continue the bank's strategy of paring back to operate core businesses more efficiently. The strategy has included emphasizing business in rapidly growing urban areas.

Of the announced restructuring charges, about 25 percent will be taken in the bank's investment and corporate banking businesses, and 10 percent in transaction services. Some 1,900 jobs are to be cut from those areas, with more than half coming from operations and technology functions that support the businesses.

One goal of the cuts is to eliminate redundant coverage of relationships with corporate clients, long a source of inefficiency at Citigroup, where sometimes multiple bankers handle relationships with companies and pitch them loans, deal advice, securities underwriting and other services.

The moves will "streamline our client coverage model," the bank said.

Another 25 percent of the charges are for reworking corporate and miscellaneous other functions. About 2,600 jobs are being eliminated from corporate support services, global functions, real estate and the Citi Holdings portfolio of troubled assets that the company is shedding.

The announcement did not say how Corbat intends to organize his executive team or whether he will fill the position of chief operating officer, which was left open when John Havens departed with Pandit.

Even before the Citigroup move, major banks had announced some 160,000 job cuts since early last year, according to a Reuters analysis in November. [ID:nL5E8MDASH] Among the largest: Bank of America in September 2011 announced 30,000 layoffs as part of a plan to reduce annual expenses by $8 billion. That bank is also closing or selling 750 branches.

In October, Swiss bank UBS unveiled plans to fire 10,000 staff and wind down its fixed income business.

Citigroup has been announcing job cuts and expense reductions for years. In April 2007 it announced 17,000 job cuts, meant to help save $4.6 billion of annual expenses by 2009.

In November 2008, as the financial crisis was in full flush, Pandit announced plans to cut more than 50,000 jobs. In December 2011, Pandit said the bank was cutting 4,500 positions, and said he aimed to cut costs by 3 percent to 5 percent annually.

(Reporting by David Henry and Dan Wilchins in New York and Rick Rothacker in Charlotte, North Carolina; Editing by John Wallace)

Source: http://news.yahoo.com/citigroup-cut-11-000-jobs-worldwide-4-percent-141035171--sector.html

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Tuesday, December 4, 2012

Taylor Swift Please Make This Relationship With Harry Styles Work ...

If Taylor Swift had a theme song, it would probably be?Tupac's?"I Get Around."?

Less than one month after breaking up with Connor Kennedy -?the 18-year-old whom she dated and purchased a $4 million dollar mansion next door to - Taylor is now dating Harry Styles, also 18! ?

NEW COUPLE ALERT: Taylor Swift and Harry Styles Date In NYC

Real estate agents in England are just drooling at the chance to make Taylor a client. In all seriousness though, Taylor hasn't had much luck when it comes to relationships, although she's had luck avoiding being called any nasty names.?

Names that plague others like Kim Kardashian, Paris Hilton, and Wilmer Valderrama.

Since she's had luck avoiding the promiscuous name-calling, I really hope that she can make this relationship with the One Direction singer be more of a romance than a quick fling.?

Taylor deserves love; she's starting to know that she's been around the block a few times. She joked with Ellen:

"Stop it, this makes me feel so bad about myself. Every time I come up here, you put a picture of me with a different dude on the screen. And it makes me question what I stand for as a human being. There have never been two guys up there two visits in a row. It's sad."

Is it finally time for Taylor to have a change of heart? She's already struck out with so many quote-unquote good men.

Joe Jonas inspired her song, "Forever and Always," and he lasted about 3 months.?There was Taylor Lautner, whom she met on the set of Valentine's Day. Their romance didn't make to Valentine's Day. She shagged international man of leisure, John Mayer, and when that ended, she made a song called "Dear John."?

Add in Cory Monteith, Jake Gyllenhaal ("We Are Never Ever Getting Back Together,") Conor Kennedy, and a few others whom we can't confirm but assume she dated, and it all starts to add up.?

While Taylor's failed relationships lead to some good music, it's time for her to find love. She really does make a good couple with pop heartthrob Harry, so let's hope they make a true love connection. Pop music needs this!

~?Blog Xilla Follow Me On Twitter

Xilla is the Sr. Entertainment Editor for GlobalGrind.com as well as CEO of the number 1 relationship blog?BlogXilla.com/M2TB.com. He has been featured in XXL, The Source, Essence, LA Times and is considered one of the premiere bloggers in the industry. Follow him on twitter?@BlogXilla

Source: http://globalgrind.com/entertainment/taylor-swift-please-make-relationship-harry-styles-work-out-blog-blogxilla

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Amnesty details 'horrific' abuses in south Yemen

SANAA, Yemen (AP) ? Al-Qaida committed "horrific" rights abuses during its 16 months in power in southern Yemen, Amnesty International charged in a report released Tuesday, documenting the beheading of an alleged sorcerer, crucifixion of a man accused spying and amputation of a man's hand for stealing.

The rights abuses between February 2011 and June 2012, when al-Qaida in the Arabian Peninsula's (AQAP) affiliate Ansar al-Shariah took over parts of southern Yemen, resulted in "a human rights catastrophe," according to the London-based rights group.

The report also accuses Yemen's government of abuses.

"We believe that horrific human rights abuses took place and violations of international humanitarian law by both sides," according to author of the report, Celina Nasser.

Al-Qaida's takeover of large swaths of territory in southern Yemen was the first time the group has governed entire towns and cities.

The 57-page report, titled "Conflict in Yemen: Abyan's Darkest Hour," documents some of the violations during the conflict between Yemeni government forces and Ansar al-Shariah. It also sheds light on how al-Qaida militants ran government affairs.

Al-Qaida militants seized Zinjibar, the capital of Abyan province on the Arabian Sea coast, while Yemen was mired in the turmoil of a popular uprising against then-President Ali Abdullah Saleh. The militants also took control of several nearby towns. Saleh, once a U.S. ally, stepped down in February under a Gulf-mediated, U.S.-backed deal.

Al-Qaida set up committees to rule southern Yemen. Their rulings and punishments were documented in videos released by al-Qaida in Yemen's media arm. Amnesty compiled some in a nearly 10-minute video released with the report.

The video shows a man in front of a crowd holding the severed head of a woman accused of sorcery. Other scenes show amputation of a man's left hand in a public square in the town of Jaar in southern Yemen. He was accused of stealing electronic wires. Without a trial or prior knowledge of the punishment, he wakes up to find his hand was cut off.

"They gave me an injection, and I slept ... when I woke up, my hand was not there," the man told Amnesty.

Another scene shows the bloated body of a man who was killed and crucified in a public square.

Stores were forcibly closed during the five daily Muslim prayers. A woman tells Amnesty that an Ansar al-Shariah militant banned men from entering her store.

"I would keep the door open, so he hung a curtain to make sure that no one could see me," she said.

The group also forced women to not only cover their faces, as is tradition in Yemen, but also to cover their eyes.

In May, the group destroyed tombs and shrines that they regarded as idolatrous in three villages in the governorate of Abyan.

Around a quarter-million people were displaced due to the conflict. The World Food Program says that more than 10 million Yemenis - 44.5 percent of the population - are food insecure, many of them internally displaced.

Amnesty researcher, Nasser, said there were few checkpoints between the large southern city of Aden and the town of Jaar, which was the first to fall to al-Qaida and served as the group's base in the absence of government forces.

"In Jaar, I didn't see any military presence. I think those who are running the show now are the Popular Committees," she said a phone interview with The Associated Press.

The governor of Abyan province told the AP that the government has yet to rebuild schools, hospitals, roads, sewage systems or even secure the area. He said food aid is also needed.

"The Interior Ministry has not until now taken any positive steps on the ground," Jamal al-Aqil said.

Amnesty's report also points to the killing of civilians, including children, as a result of air strikes and artillery and mortar attacks by government forces trying to force out al-Qaida militants from residential areas.

Amnesty said that Yemeni government forces used inappropriate battlefield weapons such as artillery in civilian areas. In other attacks, government forces appeared to fail to take necessary precautions to spare civilians, the report said.

"We cannot rule out that some of these airstrikes were carried out by U.S. drones," Nasser told the AP. "We call on the United States to also investigate what weapons were used in these airstrikes where civilians were killed."

Washington considers the AQAP to be the network's most dangerous offshoot. The group has been blamed for directing a string of unsuccessful bomb plots on U.S. soil.

This summer, a Yemeni military campaign against AQAP in southern Yemen was orchestrated by U.S. military advisers and financially assisted by neighboring Saudi Arabia. The U.S. helped Yemenis from a command center manned by dozens of U.S. troops in the southern desert outside of the main battle zones. They coordinated assaults and airstrikes, and have carried out drone strikes.

"It's not only the Yemeni government. Any state that was supporting it, including the U.S., should bear responsibility for the killing of civilians," Nasser said.

Since the offensive drove al-Qaida from the towns, the militants have sought refuge in nearby mountain areas and retaliated with assassinations of security and military officials and suicide bombings.

Nasser warned that the conflict could renew, with both sides "committing the same violations."

___

Batrawy reported from Cairo.

Source: http://news.yahoo.com/amnesty-details-horrific-abuses-south-yemen-003012110.html

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BlackBerry 10 said to show promise, but it can?t dent iPhone or Android

Research In Motion (RIMM) shares have surged recently following a series of positive reports suggesting RIM still has money to make ahead of its upcoming BlackBerry 10 launch, and that BlackBerry 10 itself may find success despite being written off by a number of industry watchers. Bears rushed to cast doubt on a RIM comeback, however, and now a new report on Monday morning suggests any potential success RIM sees with BlackBerry 10 will likely be short-lived.

Canaccord Genuity analyst T. Michael Walkley on Monday issued a note to clients covering RIM?s recent run. He believes BlackBerry 10 could offer RIM some brief aid but in the long term, he doesn?t see the new platform gaining momentum against market leaders.

?Over the past month, RIM shares have markedly increased ahead of the January 30 launch of long-awaited high-tier BlackBerry 10 smartphones,? Walkley wrote.??While initial sales of higher-ASP BlackBerry 10 smartphones should improve RIM?s January and May quarter device sales and ASP mix, our checks and analysis of the global competitive landscape suggest a very low probability BlackBerry 10 sales can turn around RIM?s long-term business trends.?

The analyst continued, ?Our checks indicate high-ARPU consumers continue to switch from BlackBerry to sticky iPhone and Android ecosystems in droves, BYOD (bring your own device) trends continue to lower RIM?s higher-ARPU enterprise base, and sub-$200 3G Android smartphones in emerging markets threaten RIM?s global sales and subscriber base. While we believe BB10 is a dramatically improved user experience versus BB7 and RIM?s new hardware is more competitive with higher-end smartphones, our checks do not indicate the consumer pull, carrier push, or developer excitement necessary for BlackBerry 10 to reverse the challenging trends faced by RIM in order to return the company to sustained profitability.?

Walkley has downgraded RIM shares to Sell, noting that BlackBerry 10 will likely not return RIM to sustained?profitability.

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Source: http://news.yahoo.com/blackberry-10-said-show-promise-t-dent-iphone-141544490.html

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Childhood trauma leaves mark on DNA of some victims: Gene ...

Abused children are at high risk of anxiety and mood disorders, as traumatic experience induces lasting changes to their gene regulation. Scientists from the Max Planck Institute of Psychiatry in Munich have now documented for the first time that genetic variants of the FKBP5 gene can influence epigenetic alterations in this gene induced by early trauma.

In individuals with a genetic predisposition, trauma causes long-term changes in DNA methylation leading to a lasting dysregulation of the stress hormone system. As a result, those affected find themselves less able to cope with stressful situations throughout their lives, frequently leading to depression, post-traumatic stress disorder or anxiety disorders in adulthood. Doctors and scientists hope these discoveries will yield new treatment strategies tailored to individual patients, as well as increased public awareness of the importance of protecting children from trauma and its consequences.

Many human illnesses arise from the interaction of individual genes and environmental influences. Traumatic events, especially in childhood, constitute high risk factors for the emergence of psychiatric illnesses in later life. However, whether early stress actually leads to a psychiatric disorder depends largely on his or her genetic predisposition.

Research Group Leader Elisabeth Binder of the Max Planck Institute of Psychiatry examined the DNA of almost 2000 Afro-Americans who had been repeatedly and severely traumatised as adults or in childhood. One-third of trauma victims had become ill and was now suffering from post-traumatic stress disorder. The risk of developing post-traumatic stress disorder rose with increasing severity of abuse only in the carriers of a specific genetic variant in the FKBP5 gene. FKPB5 determines how effectively the organism can react to stress, and by this regulates the entire stress hormone system. The scientists hoped to cast light on the mechanisms of this gene-environment interaction by comparing modifications of the DNA sequence of victims who had not become ill with that of those who had.

The Munich-based Max Planck scientists were then able to demonstrate that the genetic FKBP5 variant does make a physiological difference to those affected, also in nerve cells. Extreme stress and the associated high concentrations of stress hormones bring about what is called an epigenetic change. A methyl group is broken off the DNA at this point, causing a marked increase in FKBP5 activity. This lasting epigenetic change is generated primarily through childhood traumatisation. Consequently, no disease-related demethylation of the FKBP5 gene was detected in participants who were traumatised in adulthood only.

Torsten Klengel, a scientist at the Max Planck Institute of Psychiatry, explains the findings of the study as follows: ?Depending on genetic predisposition, childhood trauma can leave permanent epigenetic marks on the DNA, further de-repressing FKBP5 transcription. The consequence is a permanent dysregulation of the victim?s stress hormone system, which can ultimately lead to psychiatric illness. Decisive for victims of childhood abuse, however, is that the stress-induced epigenetic changes can only occur if their DNA has a specific sequence.?

This recent study improves our understanding of psychiatric illnesses which arise from the interaction of environmental and genetic factors. The results will help tailor treatment particularly for patients who were exposed to trauma in early childhood, thereby greatly increasing their risk of illness.


Story Source:

The above story is reprinted from materials provided by Max-Planck-Gesellschaft.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Torsten Klengel, Divya Mehta, Christoph Anacker, Monika Rex-Haffner, Jens C Pruessner, Carmine M Pariante, Thaddeus W W Pace, Kristina B Mercer, Helen S Mayberg, Bekh Bradley, Charles B Nemeroff, Florian Holsboer, Christine M Heim, Kerry J Ressler, Theo Rein, Elisabeth B Binder. Allele-specific FKBP5 DNA demethylation mediates gene?childhood trauma interactions. Nature Neuroscience, 2012; DOI: 10.1038/nn.3275

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Article source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/mental_health/~3/A6x4bs8YQOQ/121202164057.htm

Source: http://www.mhhub.com/archives/26369

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